Kim, D.J.,  Bility, M.T., Billin, A.N., Willson, T.M., Gonzalez, F.J. and Peters, J.M..  Peroxisome proliferator-activated receptor-b/d selectively induces differentiation and inhibits cell proliferation. Cell Death and Differentiation  (2005) In Press.

Burdick, A.D., Kim, D.J., Peraza, M.A., Gonzalez, F.J. and Peters, J.M..  The role of peroxisome proliferator-activated receptor-b/d in epithelial cell growth and differentiation. Cellular Signaling (2005) In Press. INVITED REVIEW.

Murray, I.A., Reen R.K., Leathery, N., Ramadoss, P., Bonati, L., Gonzalez, F.J., Peters, J.M., and Perdew G.H. Evidence that ligand binding is a key determinant of Ah receptor-mediated transcriptional activity. Archives of Biochemistry and Biophysics  (2005) In Press.

Polak, P., Kalinin, S., Russo, C.D., Gavrilyuk, V., Sharp, A., Peters, J.M., Richardson, J., Willson, T.M., Weinberg, G. and Feinstein, D.L.. Protective effects of a peroxisome proliferators-activated receptor-b/d agonist in experimental autoimmune encephalomyelitis. Journal of Neuroimmunology (2005) In Press.

Peters, J.M., Cheung, C. and Gonzalez, F.J..  Peroxisome proliferator-activated receptor-a (PPARa) and liver cancer:  Where do we stand? Journal of Molecular Medicine  (2005) In Press.

Kim, D.J., Murray, I., Burns, A.M., Gonzalez, F.J., Perdew, G.H. and Peters, J.M. Peroxisome proliferator-activated receptor-b (PPARb) attenuates epidermal cell proliferation via ubiquitin-dependent down-regulation of kinase activity. The Journal of Biological Chemistry  (2005) 280:9519-9527.

Hays, T., Rusyn, I., Burns, A.M., Gonzalez, F.J., Kennett, M.J., Ward, J.M. and Peters, J.M.. Role of the peroxisome proliferator-activated receptor a (PPARa) in bezafibrate-induced hepatocarcinogenesis.  Carcinogenesis (2005) 26:219-227.

Clemencet, M.C.,  Muzio, G., Trombetta, A.,  Peters, J.M., Gonzalez, F.J.,  Canuto, R.A. and Latruffe, N.. Differences in cell proliferation in rodent and human hepatic derived cell lines exposed to ciprofibrate.  Cancer Letters (2005) In Press.

Duez, H., Lefebvre, B., Poulain, P., Torra, I. P., Percevault, F., Luc, G., Peters, J.M., Gonzalez, F.J.,  Gineste, R., Helleboid, S, Fruchart, J.C., Fievet, C., Lefebvre, B. and Staels, B..  Regulation of human apo A-I by gemfibrizil and fenofibrate via selective peroxisome proliferator-activated receptora modulation. Arteriosclerosis, Thrombosis, and Vascular Biology  (2005) 25: 585-591.

Peters, J.M., Kato, S. and Gonzalez, F.J.. The United States-Japan workshop on: The role of nuclear receptors in carcinogenesis.  Molecular Carcinogenesis (2004) 41:77-84.

Harman, F., Nicol, C.J., Marin, H.E., Ward, J.M., Gonzalez, F.J. and Peters. J.M. Peroxisome proliferator-activated receptor-d/b (PPARd/b) attenuates colon carcinogenesis.  Nature Medicine  (2004) 10:481-483.

Matsusue, K., Peters, J.M.* and Gonzalez, F.J.. Peroxisome proliferators-activated receptor b (PPARb) potentiates PPARg-stimulated adipogenesis.   The FASEB Journal (2004) 18:1477-1479.  *Equally contributing first author.

Kim, D.J., Akiyama, T. E., Harman, F., Burns, A.M., Shan, W., Ward, J.M., Kennett, M.J., Gonzalez, F.J. and Peters, J.M. PPARb(d)-dependent regulation of ubiquitin C expression contributes to attenuation of skin carcinogenesis.   The Journal of Biological Chemistry  (2004) 279:23719-23727.

Bility, M.T., Thompson, J., McKee, R.H., David, R.M., Butala, J.H., Vanden Heuvel, J.V. and Peters, J.M.. Activation of mouse and human peroxisome proliferator-activated receptors (PPARs) by phthalate monoesters. Toxicological Sciences (2004) 82:170-182.

Rusyn, I., Asakura, S., Pachkowski, B., Bradford, B.U., Denissenko, M.F., Peters, J.M., Holland, S.M., Reddy, J.K., Cunningham, M.L. and Swenberg, J.A. Expression of base excision DNA repair genes is a sensitive biomarker for in vivo detection of chemical-induced chronic oxidative stress:  Identification of the molecular source of radicals responsible for DNA damage by peroxisome proliferators. Cancer Research  (2004) 64:1050-1057.

Reed, K.R., Sansom, O.J., Hayes, A.J., Gescher, A.J., Winton, D.J., Peters, J.M. and Clarke, A.R.. PPARd status and APC-mediated tumourigenesis in the mouse intestine. Oncogene (2004)  23:8992-8996.

Miyazaki, M., Dobrzyn, A., Sampath, H., Lee, S.-H., Man, W.C., Chu, K., Peters, J.M., Gonzalez, F.J. and Ntambi, J.M.. Reduced adiposity and liver steatosis by stearoyl-CoA desaturase deficiency are independent of peroxisome proliferator-activated receptor-a. The Journal of Biological Chemistry (2004) 279:35017-35024.

Akiyama, T.E., Lambert, G., Nicol, C.J., Matsusue, K., Peters, J.M., Brewer Jr., H.B. and Gonzalez, F.J.. Peroxisome proliferator-activated receptor b/d regulates very low density lipoprotein production and catabolism in mice on a western diet.  The Journal of Biological Chemistry (2004) 279:20874-20881.

Nicol, C.J., Yoon, M., Ward, J.M., Yamashida, M., Fukamachi, K., Peters, J.M. and Gonzalez, F.J.. PPARg deficiency increases susceptibility to DMBA-induced mammary and skin carcinogenesis.  Carcinogenesis (2004) 25:1747-1755.

Nakajima, T., Kamijo, Y., Tanaka, N., Fukushima, Y., Tanaka, E., Kiyosawa, K., Peters, J.M., Gonzalez, F.J. and Aoyama, T. Peroxisome proliferator-activated receptor a (PPARa) protects against alcohol-induced liver damage.  Hepatology  (2004) 40:972-980.

Peters, J.M., Aoyama, T., Burns, A.M. and Gonzalez, F.J.. Bezafibrate is a dual ligand for PPARa and PPARb: Studies using null mice.  Biochimica Biophysica Acta-Molecular and Cell Biology of Lipids (2003) 1632:80-89.

Tien, E.S., Gray, J.P., Peters, J.M. and Vanden Heuvel, J.P.. Comprehensive gene expression analysis of peroxisome proliferator-treated immortalized hepatocytes from the PPAR-null mouse. Cancer Research  (2003) 63:5767-5780.

Klaunig, J.E., Babich, M.A., Baetcke, K.P., Cook, J.C., Corton, J.C., David, R.M., DeLuca, J.G., Lai, D.Y., McKee, R.H., Peters, J.M., Roberts, R.A. and Fenner-Crisp, P.A.. PPARa agonist-induced rodent tumors: Mode(s) of action and human relevance. Critical Reviews in Toxicology (2003) 33:655-780.

Rosenberger, T.A., Hovda, J.T. and Peters, J.M..  Distinct gender differences in mouse brain phospholipid and esterified fatty acid levels in the absence of a functional PPARb(d). Lipids (2002) 37:495-500.

Rao, M.S., Peters, J.M., Gonzalez, F.J. and Reddy, J.K.. Hepatic regeneration in peroxisome proliferator-activated receptor a-null mice after partial hepatectomy. Hepatology Research  (2002) 22:52-57.

Ripp, S.L., Fitzpatrick,  J.L., Peters, J.M. and Prough, R.A.. Induction of CYP3A Expression by DHEA: Involvement of the Pregnane X Receptor.  Drug Metabolism and Disposition (2002) 30:570-575.

Ntambi, J.M., Choi, Y., Park, Y., Peters, J.M. and Pariza, M.W.. Effects of conjugated linoleic acid (CLA) on immune responses, body composition and stearoyl-CoA desaturase.  Canadian Journal of Applied Physiology (2002) 27:617-627.

Reynolds, K., Novosad. B., Hoffhines, A., Gipson, J., Johnson, J., Peters, J., Gonzalez, F., Gimble, J. and Hill, M.. Pretreatment with troglitazone decreases lethality during endotoxemia in mice.  Journal of Endotoxin Research (2002) 8:307-314.

Akiyama, T., Nicol, C.J., Fievet, C., Staels, B., Ward, J.M., Gonzalez, F.J., Auwerx, J. and Peters, J.M.. Peroxisome proliferator-activated receptor-a (PPARa) regulates lipid homeostasis but is not associated with obesity: Studies with congenic mouse lines. The Journal of Biological Chemistry (2001) 276:39088-39093.

Kiss, A., Ortiz-Aguayo, R., Sharp, R., Merlino, G., Thorgeirsson, S.S., Gonzalez, F.J. and Peters, J.M.. Evidence that reduction of hepatocyte growth factor (HGF) is not required for peroxisome proliferator-induced hepatocyte proliferation. Carcinogenesis (2001) 22:975-979.

Vanden Heuvel, J.P. and Peters, J.M.. Biology of the PPAR family of receptors.  Comments on Toxicology  (2001) 7: 233-258.

Peters, J.M., Park, Y., Gonzalez, F.J. and Pariza, M.W.. Influence of conjugated linoleic acid (CLA) in peroxisome proliferator-activated receptor a (PPARa)-null mice.  Biochimica Biophysica Acta -Molecular and Cell Biology of Lipids (2001) 1533:233-242.

Wu, P., Peters, J.M. and Harris, R.A.. Adaptive increase in pyruvate dehydrogenase kinase 4 during starvation is mediated by peroxisome proliferator-activated receptor a.  Biochemical and Biophysical Research Communications (2001) 287:391-396.

Dallongeville, J., Bauge, E., Tailleux, A., Peters, J.M., Gonzalez, F.J. and Staels, B.. Peroxisome proliferator-activated receptor a is not rate limiting for lipoprotein-lowering action of fish oil. The Journal of Biological Chemistry  (2001) 276:4634-4639.

Crabb, D.W., Pinaire, J., Chou, W., Sissom, S., Peters, J.M., Harris, R.A. and Stewart, M.. Peroxisome proliferator-activated receptors (PPAR) and the mitochondrial aldehyde dehydrogenase (ALDH2) promoter in vitro and in vivo.  Alcoholism: Clinical and Experimental Research (2001) 25:945-952.

Guerre-Millo, M., Rouault, C., Poulain, P., Andre, J., Poitout, V., Peters, J.M., Gonzalez, F.J., Fruchart, J.-C., Reach, G. and Staels, B..  PPARa-null mice are protected from high-fat diet-induced insulin resistance. Diabetes (2001) 50:2809-2814.

Cui, X., Kawashima, H., Barclay, T.B., Peters, J.M., Gonzalez, F.J., Morgan, E.T. and Strobel, H.W.. Molecular cloning and regulation of expression of two novel mouse CYP4F genes. Journal of Pharmacology and Experimental Therapeutics (2001) 296:542-550.

Xu, S., Zhu, B.T., Turan, V., Rusyn, I., Thurman, R., Peters, J.M., Gonzalez, F.J. and Conney, A.H..  Peroxisome proliferator-activated receptor alpha (PPARa)-dependent induction of liver microsomal esterification of estradiol and testosterone by a prototypical peroxisome proliferator. Endocrinology  (2001) 142:3554-3557.

Michalik, L., Desvergne, B., Tan. N.S., Basu-Modak, S., Escher, P., Rieusset, J., Peters, J.M., Kaya, G., Gonzalez, F.J., Zakany, J., Metzger, D., Chambon, P., Duboule, D. and Wahli, W.. Impaired skin wound healing in PPARa and PPARb mutant mice. Journal of Cell Biology  (2001) 154:799-814.

Rusyn, I., Kadiiska, M.B., Dikalova, A., Kono, H., Yin, M., Tsuchiya, K., Mason, R.P., Peters, J.M., Gonzalez, F.J., Segal, B.H., Holland, S.M. and Thurman, R.G.. Phthalates rapidly increase production of reactive oxygen species in vivo: Role of Kupffer cells. Molecular Pharmacology  (2001) 59:744-750.

Wheeler, M.D., Kono, H., Yin, M., Nakagami, M., Uesugi, T., Arteel, G.E., Gabele, E., Rusyn, I.,  Yamashina, S., Froh, M., Adachi, Y., Iimuro, Y., Bradford, B.U., Smutney, O.M., Connor, H.D., Mason, R.P., Goyert, S.M., Peters, J.M., Gonzalez, F.J., Samulski, R.J. and Thurman, R.G.. The role of Kupffer cell oxidant production in early ethanol-induced liver injury. Free Radical Biology and Medicine  (2001) 31:1544-1549.

Peters, J.M., Lee,  S.S.T., Li,  W., Ward,  J.M., Gavrilova,  O., Everett, C., Reitman, M.L., Hudson,  L.D. and Gonzalez, F.J.. Growth, adipose, brain and skin alterations resulting from targeted disruption of the mouse peroxisome proliferator-activated receptor b(d).  Molecular and Cellular Biology  (2000) 20:5119-5128.

Peters, J.M., Rusyn, I., Rose, M.L., Gonzalez, F.J. and Thurman,  R.G.. Peroxisome proliferator-activated receptor a is restricted to hepatic parenchymal cells, not Kupffer cells: Implications for the mechanism of action of peroxisome proliferators in hepatocarcinogenesis. Carcinogenesis  (2000) 21:823-826.

Peters, J.M.  Roles of the peroxisome proliferator-activated receptors in development.  Frontiers in Fetal Health: A Global Perspective  (2000) 2:13-15.

Sapone, A., Peters,  J.M., Sakai, S., Tomita, S., Papiha, S.S., Dai, R., Friedman, F.K. and Gonzalez, F.J.. The human peroxisome proliferator-activated receptor a gene: Identification and functional characterization of two natural allelic variants. Pharmacogenetics  (2000) 10:321-334.

Turunen, M., Peters, J.M., Gonzalez, F.J., Schedin, S. and Dallner, G.. Influence of peroxisome proliferator-activated receptor a on ubiquinone biosynthesis. Journal of Molecular Biology  (2000) 297:607-614.

Wu, X., Peters, J.M., Gonzalez, F.J., Prasad, H.S., Rohrer, M.D. and Gimble, J.M.. Frequency of stromal lineage colony forming units in the bone marrow of peroxisome proliferator-activated receptora null mice. Bone  (2000) 26:21-26.

Portilla, D., Dai, G., Peters, J.M., Gonzalez, F.J., Crew, M.D. and Proia, A.D.. Etomoxir-induced PPARa-modulated enzymes protect during renal failure.  American Journal of Physiology  (2000) 278:F667-675.

Hunt, M.C., Lindquist, P.J.G., Peters, J.M., Gonzalez, F.J., Diezfalusy, U. and Alexson, S.E.H.. Involvement of the peroxisome proliferator-activated receptor a in regulating long-chain acyl-CoA thioesterases.  Journal of Lipid Research (2000) 41:814-823.

Pan, D.A., Mater, M.K., Thelen, A.P., Peters, J.M., Gonzalez, F.J. and Jump, D.B.. Evidence against the PPARa as the mediator for PUFA suppression of hepatic L-pyruvate kinase gene expression. Journal of Lipid Research (2000) 41:742-751.

Hasmall, S.C., James, N.H., Macdonald, N., Gonzalez, F.J., Peters, J.M. and Roberts, R.A..  Suppression of mouse hepatocyte apoptosis by peroxisome proliferators:  Role of PPARa and TNFa. Mutation Research (2000) 448:193-200.

Holden, P.R., Hasmall, S.C., James, N.H., West, D.R., Brindle, R.D., Gonzalez, F.J., Peters, J.M. and Roberts, R.A.. Tumour necrosis factor a (TNFa):  Role in suppression of apoptosis by the peroxisome proliferator nafenopin. Cellular and Molecular Biology (2000) 46:29-39.

DeLuca, J.G., Doebber, T.W., Kelly, L.J., Kemp, R.E., Molon-Noblot, S., Sahoo, S.P., Ventre, J., Wu, M.S., Peters, J.M., Gonzalez, F.J. and Moller, D.E.. Evidence for PPARa-Independent Peroxisome Profliferation: Effects of PPARg/d-Specific Agonists in PPARa Null Mice.  Molecular Pharmacology  (2000) 58:470-476.

Peters, J.M, Narotsky, M.G., Elizondo, G., Fernandez-Salguero, P.M., Gonzalez, F.J. and Abbott,  B.D.. Amelioration of TCDD-induced teratogenesis in aryl hydrocarbon receptor (AHR)-null mice. Toxicological Sciences  (1999) 47:86-92.

Peters, J.M., Morishima, H., Ward, J.M., Coakley, C.J., Kimura, S. and Gonzalez, F.J.. Role of CYP1A2 in the toxicity and carcinogenicity of long-term phenacetin feeding. Toxicological Sciences  (1999) 50:82-89.

Barclay, T.B., Peters, J.M., Sewer, M.B., Ferrari, L., Gonzalez, F.J. and Morgan, E.T.. Modulation of cytochrome P-450 gene expression in endotoxemic mice is tissue specific and peroxisome proliferator-activated receptor-a-dependent. Journal of Pharmacology and Experimental Therapeutics  (1999) 290:1250-1257.

Kersten, S., Seydoux, J., Peters, J.M., Gonzalez, F.J., Desvergne, B. and Wahli, W..  Peroxisome proliferator-activated receptor a mediates the adaptive response to fasting. The Journal of Clinical Investigations (1999) 103:1489-1498.

Constan, A.A., Sprankle, C.S., Peters, J.M., Kedderis, G.L., Everitt, J.I., Wong, B.A., Gonzalez, F.J. and Butterworth, B.E.. Metabolism of chloroform by cytochrome P450 2E1 is required for induction of toxicity in the liver, kidney and nose of male mice. Toxicology and Applied Pharmacology  (1999) 160:120-126.

Guidotti, L.G., Eggers, C.M., Raney, A.K., Chi, S.Y., Peters, J.M., Gonzalez, F.J. and McLachlan, A.. In vivo regulation of hepatitis B virus replication by peroxisome proliferators. The Journal of Virology  (1999) 73:10377-10386.

Hashimoto, T., Fujita, T., Usuda, N., Cook, W., Qi, C., Peters, J.M., Gonzalez, F.J., Yeldandi, A.V., Rao, M.S. and Reddy, J.K.. Peroxisomal and mitochondrial fatty acid -oxidation in mice nullizygous for both PPARa and fatty acyl CoA oxidase:  Genotype correlation with fatty liver phenotype.The Journal of Biological Chemistry  (1999) 274:19228-19236.

Delerive, P., De Bosscher, K., Besnard, S., Vanden Berghe, W., Peters, J.M., Gonzalez, F.J.,  Fruchart, J.-C., Tedgui, A., Haegeman, G. and Staels, B.. Peroxisome proliferator-activated receptora negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NF-B and AP-1. The Journal of Biological Chemistry  (1999) 274:32048-32054.

Hill, M.R., Clarke, S., Rodgers, K., Hoebing, B., Peters, J.M., Gonzalez, F.J. and Gimble, J.M..  Effect of peroxisome proliferator-activated receptor alpha activators on tumor necrosis factor expression in mice during endotoxemia. Infection and Immunity  (1999) 67:3488-3493.

Kockx, M., Gervois, P.P., Poulain, P., Derudas, B., Peters, J.M., Gonzalez, F.J., Prineen, H.M.G. and Staels, B.. Fibrates suppress fibrinogen gene expression in rodents via activation of the peroxisome proliferator-activated receptor. Blood (1999) 93:2991-2998.

Kono, H., Bradford, B.U., Yin, M., Sulik, K.K., Koop, D.R., Peters, J.M., Gonzalez, F.J., McDonald, T., Nikolova, A., Kadiiska, M., Mason, R.P. and Thurman,  R.G.. CYP2E1 is not involved in early alcohol-induced liver injury. American Journal of Physiology  (1999) 277:G1259-G1267.

Peters, J.M., Aoyama, T., Cattley, R.C., Usuda, N., Hashimoto, T. and Gonzalez, F.J.. The role of peroxisome proliferator-activated receptor-a in altered cell cycle regulation in mouse liver. Carcinogenesis  (1998) 19:1989-1994.

Aoyama, T., Peters, J.M., Iritani, N., Nasu-Nakajima, T., Furihata, K., Hashimoto, T. and Gonzalez, F.J..  Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor a (PPARa) The Journal of Biological Chemistry  (1998) 273:5678-5684.

Gonzalez, F.J., Peters, J.M. and Cattley, R.C.. Mechanism of action of the non-genotoxic peroxisome proliferators:  Role of the peroxisome proliferator-activated receptor a (PPARa).  The Journal of the National Cancer Institute  (1998) 90: 1702-1709.  (REVIEW)

Ward, J.M., Peters, J.M., Perella, C.M. and Gonzalez, F.J.. Receptor and non-receptor-mediated organ-specific toxicity of di(2-ethylhexyl) phthalate (DEHP) in peroxisome proliferator-activated receptor-a-null mice. Toxicologic Pathology  (1998) 26:240-246.

Motojima, K., Passilly, P., Peters,  J.M., Gonzalez, F.J. and Latruffe, N.. Expression of putative fatty acid transporter genes are regulated by PPARa and g activators in a tissue- and inducer-specific manner.  The Journal of Biological Chemistry (1998) 273:16710-16714.

Peters, J.M., Hennuyer, N., Staels, B., Fruchart, J.-C., Fievet, C., Gonzalez, F.J. and Auwerx, J..  Alterations in lipoprotein metabolism in PPARa deficient mice. The Journal of Biological Chemistry  (1997) 272:27307-27312.

Peters, J.M., Cattley, R.C. and Gonzalez, F.J.. Role of PPARain the mechanism of action of the non-genotoxic carcinogen and peroxisome proliferator Wy 14,643. Carcinogenesis (1997) 18:2029-2033.

Peters, J.M., Taubeneck, M.W., Keen, C.L. and Gonzalez, F.J.. Di(2-ethylhexyl) phthalate induces a functional zinc deficiency and teratogenesis during pregnancy independent of peroxisome proliferator-activated receptor-a. Teratology  (1997) 56:311-316.

Ren, B., Thelen, A.P., Peters, J.M., Gonzalez, F.J. and Jump, D.B.. Polyunsaturated fatty acid suppression of hepatic S14 gene transcription does not require PPARa. The Journal of Biological Chemistry  (1997) 272:26827-26832.

Motojima, K., Peters, J.M. and Gonzalez, F.J.. PPARa mediates peroxisome proliferator-induced transcriptional repression of non-peroxisomal gene expression in the mouse. Biochemical  Biophysical Research Communications  (1997) 230:155-158.

Hanna, L., Peters, J.M., Wiley, L.M., Clegg,  M.S. and Keen, C.L.. Comparative effects of essential and nonessential metals on preimplantation mouse embryo development in vitro. Toxicology  (1997) 116:123-131.        

Hanna, L.A., Peters, J.M., Wiley, L.M., Zidenberg-Cherr, S.C. and Keen, C.L.  An enhancing effect of maternal zinc deficiency and ^Cs g-irradiation on the frequency of fetal malformations in mice. Teratogenesis, Carcinogenesis and Mutagenesis  (1997) 17:127-137.

Devchand, P.R., *Keller, H., *Peters, J.M., Vazquez, M., Gonzalez, F.J. and Wahli,  W.  The PPARa-leukotriene pathway to inflammation control. Nature (1996) 384: 34-43.  (*equally contributing second author)

Peters, J.M., Zhou, Y.C., Ram, P.A., Lee, S.S.T., Gonzalez, F.J. and Waxman,  D.J.. Peroxisome proliferator-activated receptor-a (PPAR-a) mediates gene induction by dehydroepiandrosterone 3b-sulfate. Molecular Pharmacology  (1996) 50:67-74.

Peters, J.M., Tsark, E.C. and Wiley,  L.M..  Radiosensitive target in the mouse embryo chimera assay: Implications that the target involves autocrine growth factor function. Radiation Research  (1996) 145: 722-729.